Adenylyl cyclase - Wikipedia
网页Adenylate cyclase (EC 4.6.1.1, also commonly known as adenyl cyclase and adenylyl cyclase, abbreviated AC) is an enzyme with systematic name ATP diphosphate-lyase (cyclizing; 3′,5′-cyclic-AMP-forming). It catalyzes the following reaction: ATP = 3′,5′-cyclic AMP + diphosphate. It has key regulatory roles in essentially all cells. [2]
Adenylyl Cyclases - Basic Neurochemistry - NCBI Bookshelf
网页Regulation of cAMP formation by neurotransmitter receptors and intracellular messenger pathways is determined by the activity of the synthetic enzyme adenylyl cyclase, also termed adenylate cyclase. Adenylyl cyclase can be activated directly by forskolin, a plant diterpene which has been useful in studies of enzyme regulation and purification.
Structure and function of adenylyl cyclases, key enzymes in …
网页2020年8月1日 · Adenylyl cyclases (ACs) are the enzymes that generate cAMP, and thus the key components of the cAMP signaling and regulation pathways. In this review we provide a brief general overview of the field, focusing on the recent breakthroughs in our understanding of the structure and function of the ACs …
腺苷酸环化酶 - 维基百科，自由的百科全书
网页腺苷酸环化酶（ adenylate cyclase ，adenyl cyclase，adenylyl cyclase，缩写AC），EC 4.6.1.1，系统名称为 ATP二磷酸裂解酶，是一种参与已知所有细胞调控的关键酶，位于细胞膜内侧 [2] 。其催化以下反应：
Adenylyl Cyclase - an overview | ScienceDirect Topics
网页Adenylyl cyclase is an enzyme that synthesizes cyclic AMP (cAMP), a crucial second messenger involved in regulating various physiological responses such as metabolism, olfaction, and cell growth. It exists in membrane-bound and soluble forms, with different isoforms having distinct tissue distributions and regulatory patterns.
Structure, Mechanism, and Regulation of Mammalian Adenylyl …
网页Breakthroughs in determining the first structures of the mammalian adenylyl cyclase catalytic core (6, 7) provide a new context for understanding the action of many regulators, both physiological and pharmacological: free metal ions, P-site inhibitors, forskolin, G-proteins, Ca 2+ /calmodulin, and protein phosphorylation.
Molecule of the Month: Adenylyl Cyclase - RCSB: PDB-101
网页Adenylyl cyclase is a signal amplifier. It acts at the center of the signaling cascade that transduces binding of hormones into cellular responses. When hormones such as adrenaline or glucagon bind to G-protein coupled receptors, they activate G-proteins, which in turn activate adenylyl cyclase. Adenylyl cyclase then performs its catalytic ...
Adenylyl Cyclase - SpringerLink
网页2018年1月1日 · Adenylyl cyclases (ACs) and ATP-pyrophosphate lyases comprise a family of enzymes that catalyze the synthesis of cyclic AMP from ATP.
Expression and functions of adenylyl cyclases in the CNS
网页2022年3月20日 · Adenylyl cyclases (ADCYs) catalyze the production of cAMP from ATP, while phosphodiesterases (PDEs) degrade cAMP to 5′-AMP [3, 4]. This review summarizes the structure, regulation, expression and functions of ADCYs in the CNS.
Structural insights into membrane adenylyl cyclases, initiators of …
网页2023年12月28日 · Membrane adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second messenger cAMP. As effector proteins of G protein-coupled receptors and other signaling pathways, ACs receive and amplify signals from the cell surface, translating them into biochemical reactions in the intracellular space and integrating different ...