Lysostaphin - Wikipedia
网页Lysostaphin is a 27 KDa glycylglycine endopeptidase, an antibacterial enzyme which is capable of cleaving the crosslinking pentaglycine bridges found in the cell wall peptidoglycan of certain staphylococci. Lysostaphin was first isolated from a culture of Staphylococcus simulans by Schindler and Schuhardt in 1964. [2]
溶葡萄球菌酶 - 百度百科
网页溶葡萄球菌酶(Lysostaphin)是一种含Zn 2+ 的金属蛋白酶，具有内切肽酶活性，能特异性水解细菌细胞壁肽聚糖五甘氨酸肽键桥（第2与第3位Gly形成的肽键），从而快速溶解细菌细胞壁而产生破壁溶菌作用 [1] 。溶葡萄球菌酶的理化性质、抗菌作用机制以及体内外药效 ...
Lysostaphin: A Staphylococcal Bacteriolysin with Potential Clinical ...
网页2010年4月19日 · Lysostaphin passes freely through the capsule layer of encapsulated staphylococci and is a cell-wall lytic enzyme. The cell-wall degrading activity of lysostaphin is primarily due to a glycyl-glycine endopeptidase activity (Figure 1), which lyses many staphylococcal strains .
Lysostaphin: Engineering and Potentiation toward Better …
网页2022年9月9日 · Lysostaphin is a potent bacteriolytic enzyme with endopeptidase activity against the common pathogen Staphylococcus aureus. By digesting the pentaglycine crossbridge in the cell wall peptidoglycan of S. aureus including the methicillin-resistant strains, lysostaphin initiates rapid lysis of planktonic and sessile cells (biofilms) and …
Lysostaphin - an overview | ScienceDirect Topics
网页Lysostaphin is a bacteriocin, encoded by Staphylococcus simulans with antibacterial activity against S. aureus, harboring an N-terminal glycyl-glycine M23 endopeptidase domain (EAD) and a C-terminal SH3b domain (CBD).
Therapeutic applications of lysostaphin against Staphylococcus aureus ...
网页Lysostaphin is a 27 kDa zinc metallo antimicrobial lytic enzyme that is produced by Staphylococcus simulans biovar staphylolyticus and was first discovered in the 1960s. Lysostaphin is highly active against S. aureus strains irrespective of their drug-resistant patterns with a minimum inhibitory concentration of ranges between 0·001 and 0·064 ...
Two-site recognition of Staphylococcus aureus peptidoglycan by ... - Nature
网页2019年11月4日 · Lysostaphin is a bacteriolytic enzyme targeting peptidoglycan, the essential component of the bacterial cell envelope. It displays a very potent and specific activity toward staphylococci,...
Therapeutic applications of lysostaphin against Staphylococcus …
网页2020年12月31日 · Lysostaphin can exert major therapeutic benefits over antibiotics: (i) Lysostaphin is highly active with MIC value ranges between 0·001 and 0·064 μg ml −1. (ii) Lysostaphin is active against drug-resistant S. aureus .
Structural and Functional Insights Into Lysostaphin–Substrate ...
网页2018年7月3日 · Lysostaphin from Staphylococcus simulans and its family enzymes rapidly acquire prominence as the next generation agents in treatment of S. aureus infections. The specificity of lysostaphin is promoted by its C-terminal cell wall targeting domain selectivity toward pentaglycine bridges in S. aureus cell wall.
Lysostaphin: A Staphylococcal Bacteriolysin with Potential Clinical ...
网页2010年4月19日 · Lysostaphin is the only class III staphylococcin described so far. It exhibits a high degree of antistaphylococcal bacteriolytic activity, being inactive against bacteria of all other genera. Infections caused by staphylococci continue to be a problem worldwide not only in healthcare environments but also in …