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Figure 1: Comparison of the biosynthesis and the total synthesis of englerin A. The cyclization event is initiated by an enyne cyclization — classified as 5-exo-dig using Baldwin's notation ...
However, cyclization of 1-formamido-6: 7-dimethoxy-2-(2â-bromo-4â: 5â-dimethoxy)phenyl-1: 2: 3: 4-tetrahydronaphthalene could not be effected. R. D. Haworth 2 was also interested in this ...
Professor of Medicinal Chemistry Joseph P. & Shirley Shipman Buckley Endowed Professor of Drug Discovery Chair, Department of Pharmacological and Pharmaceutical Sciences ...
The peroxide or peroxyl radical would then add a single O to one or more double bonds in A2E, particularly adjacent to the β-ionone ring (Gaillard et al., 2004). Cyclization of the peroxyl radical ...
The yield of the two products can be determined by gas chromatography (GC) or nuclear magnetic resonance (NMR). From the concentration of the trapping agent, the known rate constant of the radical ...
1 School of Pharmacy and Food Engineering, Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, China 2 College of Life Science and Technology, Jinan ...