The risk gene adenylyl cyclase 2 is associated with bipolar disorder, as has been repeatedly confirmed in genome-wide association studies. However, until now there has not been any proof of a ...

Copyright: © 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies. Aberrant G-protein coupled ...

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One potential mechanism by which MI may affect glucose metabolism involves the activation of specific signaling pathways in cells that participate ... The full description is in the text. AC adenylyl ...

Researchers from Children's Hospital of Philadelphia (CHOP) have tested a preclinical model for an experimental gene therapy designed to treat multiple sulfatase deficiency (MSD), a disorder that ...

It has been known for many decades that uremic bleeding and platelet dysfunction put patients at increased risk of general bleeding. The exact mechanism by which the risk is increased remains ...

Glucocorticoids (GCs) are steroid hormones fundamental to the body’s normal physiological functions and are pivotal in fetal growth and development. During gestation, the mother’s cortisol ...

1 Department of Clinical Genetics, Addenbrooke’s Hospital, Cambridge, UK 2 Department of Medicine, University of Cambridge, Addenbrooke’s Hospital Correspondence to: Dr S M Park Department of Clinical ...

Silencing D2Rs in DAN-c1 via microRNA disrupts aversive learning, further supported by optogenetic activation of DAN-c1 during training, affirming the inhibitory role of D2R autoreceptor. Intriguingly ...

Pathogenic activating point mutations in the LRRK2 kinase cause autosomal-dominant familial Parkinsońs disease (PD). In cultured cells, mutant LRRK2 causes a deficit in de novo cilia formation and ...