People who have negative expectations about a treatment actually experience more pain. Merve Karacaoglu discovered in her ...

“In patients with chronic pain, stress is generally associated with a worsening of pain symptoms and stress-induced hyperalgesia,” says a 2023 paper published in the Journal of Clinical Medicine. “In ...

While many people feel occasional physical pain, some people experience such a level of super-charged discomfort that it ...

Some of the central molecular mechanisms that lead to hyperalgesia and allodynia after peripheral tissue injury involve the spinal dorsal horn transient receptor potential vanilloid 1 (TRPV1).

Here's what causes chronic pain and how pain specialists use medications and treatments to help manage symptoms. The post How ...

The presence of an initiating noxious event or a cause of immobilization. Continuing pain, allodynia, or hyperalgesia with which the pain is disproportionate to the inciting event. Evidence at ...

[79,91] Provoked pain includes allodynia, pain in response to a normally nonpainful stimulus, and hyperalgesia, an increased response to a normally painful stimulus. Unfortunately, unlike animal ...

The neuraxial delivery of drugs has become a cornerstone in the management of pain, leveraging the pivotal roles of the dorsal root ganglion (DRG) and dorsal horn. These spinal structures are key in ...

Opioid-induced hyperalgesia (OIH) and allodynia; consider decreasing dose of current opioid or opioid rotation if OIH is suspected. COPD, cor pulmonale, decreased respiratory reserve, hypoxia ...

Opioid-induced hyperalgesia (OIH) and allodynia; consider reducing current opioid analgesic dose or rotating opioid if OIH is suspected. COPD, cor pulmonale, decreased respiratory reserve ...

chronic pain of various etiologies and opioid-induced tolerance and hyperalgesia (OIH) to identify and develop potential novel therapeutic targets for the treatment of these largely unmet medical ...