Some of the central molecular mechanisms that lead to hyperalgesia and allodynia after peripheral tissue injury involve the spinal dorsal horn transient receptor potential vanilloid 1 (TRPV1).

People who have negative expectations about a treatment actually experience more pain. Merve Karacaoglu discovered in her ...

The neuraxial delivery of drugs has become a cornerstone in the management of pain, leveraging the pivotal roles of the dorsal root ganglion (DRG) and dorsal horn. These spinal structures are key in ...

While many people feel occasional physical pain, some people experience such a level of super-charged discomfort that it ...

The Doyle lab studies the pathophysiological and signaling mechanisms (e.g. glutamatergic signaling, neuroinflammation and nitro-oxidative stress) common to the development of cognitive impairment, ...

Stress can also be a limiting factor for sleep and increase pain levels. “In patients with chronic pain, stress is generally associated with a worsening of pain symptoms and stress-induced ...

[79,91] Provoked pain includes allodynia, pain in response to a normally nonpainful stimulus, and hyperalgesia, an increased response to a normally painful stimulus. Unfortunately, unlike animal ...

Here's what causes chronic pain and how pain specialists use medications and treatments to help manage symptoms. The post How ...

The presence of an initiating noxious event or a cause of immobilization. Continuing pain, allodynia, or hyperalgesia with which the pain is disproportionate to the inciting event. Evidence at ...

Opioid-induced hyperalgesia (OIH) and allodynia; consider decreasing dose of current opioid or opioid rotation if OIH is suspected. COPD, cor pulmonale, decreased respiratory reserve, hypoxia ...