近些年来，“纳米医学”概念的出现，以其创新策略显著提升了癌症治疗的水平。X射线激活的光动力疗法和X射线激活的纳米材料用于近红外-II成像等开创性工作陆续报道。此外，抗肿瘤纳米药物可通过膀胱内灌注的方式在膀胱局部给药，而不是全身系统给药，这将保证临床转化的生物安全性。受此启发，该研究将光医学、X射线和纳米药物结合起来，对NMIBC进行全病程成像和无创治疗。

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