There are likely various genes that make people more susceptible to bipolar disorder. Max Planck scientists, led by research group leader Jan Deussing, wanted to know what function the risk gene ...

The risk gene adenylyl cyclase 2 is associated with bipolar disorder, as has been repeatedly confirmed in genome-wide association studies. However, until now there has not been any proof of a ...

The signal transduction cascade begins when adenylyl cyclase, a membrane- bound enzyme, becomes activated by G-protein molecules associated with the adrenergic receptor. Adenylyl cyclase creates ...

Combining classical yeast genetics with molecular biology, we identified genes required for both repression and derepression of ƒbp1 transcription, including almost all of the genes of the cyclic AMP ...

Pathogenic activating point mutations in the LRRK2 kinase cause autosomal-dominant familial Parkinsońs disease (PD). In cultured cells, mutant LRRK2 causes a deficit in de novo cilia formation and ...

Instead, the "sperm-swim" switch they are targeting is a cellular signalling protein called soluble adenylyl cyclase or sAC. The experimental male pill inhibits or blocks sAC. In the early study ...

Molecular Psychiatry is a scientific journal published by Nature Publishing Group. It publishes papers in biological psychiatry and, e.g., about psychiatric genetics. With an impact factor of 15. ...