The signal transduction cascade begins when adenylyl cyclase, a membrane- bound enzyme, becomes activated by G-protein molecules associated with the adrenergic receptor. Adenylyl cyclase creates ...

The risk gene adenylyl cyclase 2 is associated with bipolar disorder, as has been repeatedly confirmed in genome-wide association studies. However, until now there has not been any proof of a ...

A recent screen of ~125,000 compounds carried out at the NCATS (National Center for Advancing Translational Sciences) screening facility identified a collection of potential adenylyl cyclase ...

A new research paper was published in Oncotarget, titled "Inhibition of miR-10b treats metastatic breast cancer by targeting stem cell-like properties." As stated within the paper, despite ...

But silicone’s curing process can be inhibited by impurities. What’s cure inhibition? It’s a gross mess as shown in the image above, that’s what it is. Sadly, SLA-printed resin molds are ...

The primary goal of this research is to develop a new chemotherapeutic option for the treatment of cancer. We have chosen to develop Zn as a chemotherapeutic agent, based on our observations that Zn ...

Zasocitinib, a tyrosine kinase 2 (TYK2) inhibitor, at oral doses of ≥ 5 mg led to greater skin clearance than placebo over a period of 12 weeks, in a phase 2b study. Researchers performed a ...

Since the first US Food and Drug Administration approval of a Janus kinase (JAK) inhibitor in 2011, the number of these medications available — and their treatment indications — have continued ...

Theory of mind is typically defined as the ability to understand the thoughts, beliefs, desires, and emotions of other people. This understanding allows individuals to predict how others will feel ...

Salzinger, Kurt 1991. What should a theory of schizophrenia be able to do?. Behavioral and Brain Sciences, Vol. 14, Issue. 1, p. 44.

More information: Paromita Sen et al, A bipolar disorder-associated missense variant alters adenylyl cyclase 2 activity and promotes mania-like behavior, Molecular Psychiatry (2024). DOI: 10.1038 ...