21-Hydroxylase Deficiency - StatPearls - NCBI Bookshelf
网页2023年7月31日 · 21-hydroxylase deficiency is an autosomal recessive disorder caused by a deficiency in one of the enzymes required for the synthesis of cortisol in the adrenal glands. 21-Hydroxylase deficiency is the most common cause of congenital adrenal hyperplasia but can be a challenge to diagnose and treat.
The aromatic amino acid hydroxylases: Structures, catalysis, and ...
网页2023年2月1日 · The aromatic amino acid hydroxylases phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase are non-heme iron enzymes that catalyze key physiological reactions. This review discusses the present understanding of the common catalytic mechanism of these enzymes and recent advances in understanding the …
Phenylalanine hydroxylase: function, structure, and regulation
网页Mammalian phenylalanine hydroxylase (PAH) catalyzes the rate-limiting step in the phenylalanine catabolism, consuming about 75% of the phenylalanine input from the diet and protein catabolism under physiological conditions.
Tyrosine Hydroxylase - an overview | ScienceDirect Topics
网页Tyrosine hydroxylase (TH), a member of an enzymatic family that performs hydroxylation of amino acids, is a rate-limiting enzyme involved in the biosynthesis of catecholamines including DA, norepinephrine (NE), and epinephrine (E) (Nagatsu, Levitt, & …
Mechanisms of Tryptophan and Tyrosine Hydroxylase - PMC
网页Tryptophan hydroxylase (TrpH) and tyrosine hydroxylase (TyrH) catalyze the hydroxylation of the side chains of their aromatic amino acid substrates in the first step in the biosyntheses of serotonin and the catecholamine neurotransmitters, forming 5-hydroxytryptophan and 3,4-dihydroxyphenylalanine, respectively (Fig. 1).
Tryptophan Hydroxylase: Molecular Biology and Regulation
网页Tryptophan hydroxylase [TPH, tryptophan 5-monooxygenase; L-tryptophan, tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating), E.C. 1.14.16.4] catalyzes the first and rate-limiting step in the biosynthesis of serotonin (5-HT, 5’-hydroxytryptamine)...
Oxygen sensing by HIF hydroxylases - Nature
网页2004年5月1日 · Key Points. Hypoxia-inducible factor (HIF) is an α/β heterodimeric DNA-binding complex that directs an extensive transcriptional response to hypoxia. The activity of HIF is induced in hypoxic...
Bacterial steroid hydroxylases: enzyme classes, their functions and ...
网页2018年7月21日 · Bacterial hydroxylases, being a part of steroid catabolic pathways, play an important role in steroid degradation. They participate in both cholesterol and cholate degradation pathways by initiating the degradation of the aliphatic side chain or the opening of the sterane ring.
Hydrolase - an overview | ScienceDirect Topics
网页Hydrolases are a large group of enzymes that makes a significant contribution to the biodegradation of pesticides. For hydrolysis, it catalyzes a variety of important biochemicals of different categories, such as esters, peptide bonds, carbon-halide bonds, ureas, and thioesters (Scott et al., 2008).
Hydroxylation - an overview | ScienceDirect Topics
网页Hydroxylation is the process of adding a hydroxyl group (-OH) to proteins, particularly collagen and elastin, to enhance tissue stability through protein cross-linking reactions. AI generated definition based on: Encyclopedia of Cell Biology, 2016. About this page. Add to Mendeley. Chapters and Articles.
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